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目的探讨拉坦前列素对体外培养的猪毛囊生物学特性的影响。方法采用猪毛囊体外培养模型,记录体外培养的猪毛囊生长速度和毛球部形态学改变,评价拉坦前列素对毛发生长的作用。结果与阴性对照组比较,拉坦前列素质量浓度达到0．8ng/mL时即能使培养的猪毛囊生长速度加快(P＜0．05),并持续生长达8 d,且毛囊毛球部仍然呈现生长期样形态,而对照组则表现为退行期／休止期样外观。结论拉坦前列素对体外培养的猪毛囊生长具有明显的促进作用。能够延长毛囊的生长期。
Objective To investigate the effects of latanoprost on the biological characteristics of porcine hair follicles cultured in vitro. Methods Porcine hair follicles were cultured in vitro and the growth of porcine hair follicles and the morphological changes of hair bulb in vitro were recorded to evaluate the effect of latanoprost on hair growth. Results Compared with the negative control group, when the concentration of latanoprost reached 0.8ng / mL, the growth of the cultured pig hair follicles was accelerated (P <0.05), and continued to grow for up to 8 days, and hair follicle hair bulb Still showing the morphology of the growth phase, while the control group showed the appearance of the degenerative / quiescent appearance. Conclusion Latanoprost has a significant promoting effect on the growth of porcine hair follicles cultured in vitro. Can extend the growth of hair follicles.