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目的:探讨妊娠早期合并甲状腺功能异常对分娩并发症发生的影响。方法:选取2014年2月到2016年3月广州市妇女儿童医疗中心150例产妇作为研究对象,其中75例甲状腺功能异常者作为观察组,75例甲状腺功能正常者作为对照组。对比两组产妇并发症的发生情况,并检测TSH、FT4、TPOAb。结果:观察组妊娠早期、妊娠中期、分娩时、脐带血TSH、FT4、TPOAb水平与对照组比较,差异有统计学意义(均P<0.05)。观察组流产患者占比高于对照组,新生儿体质量低于对照组(均P<0.05)。观察组早产、妊娠期高血压、妊娠期糖尿病者占比均高于对照组(均P<0.05)。结论:妊娠早期合并甲状腺功能异常产妇若不能得到有效的治疗,流产、妊娠期糖尿病以及妊娠期高血压疾病发生几率高于甲状腺正常产妇,应及时发现并给予相应的治疗,减少产科并发症发生。
Objective: To investigate the impact of early pregnancy combined with thyroid dysfunction on the complications of labor. Methods: From February 2014 to March 2016, 150 maternal women in Guangzhou Women and Children Medical Center were selected as the research object. Among them, 75 cases of thyroid dysfunction as observation group and 75 cases of normal thyroid function as control group. Comparing the incidence of maternal complications in both groups and detecting TSH, FT4, TPOAb. Results: The levels of TSH, FT4 and TPOAb in umbilical cord blood in early pregnancy, mid-gestation and childbirth in observation group were significantly different from those in control group (all P <0.05). The proportion of abortion patients in the observation group was higher than that of the control group, and the body weight of neonates was lower than that of the control group (all P <0.05). The proportion of preterm birth, gestational hypertension and gestational diabetes in observation group were higher than those in control group (all P <0.05). Conclusion: If pregnant women with abnormal thyroid function in early pregnancy may not be treated effectively, the incidence of miscarriage, gestational diabetes mellitus and pregnancy-induced hypertension is higher than that of normal thyroid glands. The corresponding treatment should be promptly discovered and treated to reduce the incidence of obstetric complications.