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Ｗｉｓｔａｒ大鼠饮３０和５０ｍｇ／Ｌ高氟（Ｆ）水造成慢性氟中毒，同时另外两组大鼠饮高Ｆ水、饲２ｍｇ／ｋｇ加硒（Ｓｅ）饲料。１年内每月测饮水、摄食和排尿量，而后计算其日平均摄Ｆ、排Ｆ量，并每月测尿液Ｆ含量。喂养至４、８、１４个月时将大鼠分３批处死，测尿液、肝脏、血清Ｓｅ和骨骼、肝脏、肾脏、血清Ｆ含量。结果两组氟中毒大鼠与对照组比较摄Ｆ量升高，排Ｆ／摄Ｆ比值降低。尿Ｆ的升高与水Ｆ浓度及饮Ｆ时间呈正相关。骨、肝Ｆ大量蓄积出现于氟中毒中期，血Ｆ在氟中毒晚期明显上升。同未加Ｓｅ氟中毒大鼠比较，两组加Ｓｅ组大鼠尿、肝、血Ｓｅ升高。与此同时大鼠摄食、饮水状况改善，体重增加；排尿量升高；尿Ｆ排泄量和排Ｆ／摄Ｆ比显著提高；同时骨、肝、肾和血清Ｆ含量降低。
Chronic fluorosis was induced in Wistar rats by drinking 30 and 50 mg / L of high fluoride (F) water, while the other two groups of rats were fed with high F water and 2 mg / kg selenium (Se) feed. A monthly measurement of drinking water, food intake and urine output, and then calculate the daily average F, F row, and monthly urine F content. Rats were sacrificed in 3 batches at 4, 8 and 14 months after feeding. Urine, liver, serum Se and bone, liver, kidney and serum F contents were measured. Results Compared with the control group, rats in fluorosis group had higher F uptake and lower F / F ratio. Urinary F increased with water F concentration and drinking F time was positively correlated. The accumulation of bone and liver F appeared in the middle of fluorosis, and the blood F increased significantly in the later period of fluorosis. Compared with the rats without Se poisoning, the urinary, hepatic and blood Se levels of rats in two groups plus Se increased. At the same time, rats fed on the diet improved drinking water, increased body weight; increased urination; urinary F excretion and row F / F ratio increased significantly; the same time, bone, liver, kidney and serum F decreased.