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目的探究含雷贝拉唑的四联方案根除幽门螺杆菌的疗效。方法将98例快速尿素酶和病理学检查幽门螺杆菌(Hp)阳性的患者随机分成观察组与对照组,观察组采用雷贝拉唑+铋剂+克拉霉素+阿莫西林的四联疗法治疗,对照组采用奥美拉唑+铋剂+克拉霉素+阿莫西林的四联疗法治疗,对比分析两组患者治疗结束4周后的Hp根治率。结果观察组的Hp根除率为95.92%,对照组的Hp根除率为77.55%,观察组明显高于对照组,差异具有统计学意义(P<0.05);两组患者用药后不良反应发生率和用药费用差异无统计学意义(P>0.05)。结论含雷贝拉唑的四联方案治疗幽门螺杆菌疗效好,可作为治疗幽门螺杆菌一线治疗方案。
Objective To investigate the curative effect of helicobacter pylori eradication with quadruple regimen containing rabeprazole. Methods 98 cases of rapid urease and pathological examination of Helicobacter pylori (Hp) positive patients were randomly divided into observation group and control group, the observation group with the rabeprazole + bismuth + clarithromycin + amoxicillin quadruple therapy The patients in the control group were treated with omeprazole + bismuth + clarithromycin + amoxicillin in combination therapy, and the cure rate of Hp was compared between the two groups after 4 weeks of treatment. Results The Hp eradication rate was 95.92% in the observation group and 77.55% in the control group, which was significantly higher in the observation group than in the control group (P <0.05). The incidence of adverse reactions, There was no significant difference in medication cost (P> 0.05). Conclusion The quadruple regimen containing rabeprazole is effective in treating H. pylori and can be used as a first-line treatment for Helicobacter pylori.