Billroth Ⅰ operation is the best procedure to do the subtotal gastrectomy for duodenal ulcer. It restores the gastroduodenal continuation and decreases complications. In the past, however, when there were too many scars in the ulcer, only Billroth Ⅱ operation was performed. Today, surgical treatment for duodenal ulcer has been reduced significantly in big hospitals due to the good results achieved by medical treatment. But the operation becomes more difficult for patients in whom the medical treatment fails. Moreover, most of these patients receive traditional operations at the grass roots hospitals and can not be treated effectively. In a period of 11 years, we have performed anastomosis of duodenal mucosa with gastric wall following the principle of Billroth Ⅰ operation on 45 cases with good results. Here we report our experience.