5-羟色胺选择性再摄取抑制剂（SSRIs）应用以来，常有报道这些药物有时能促进精神抑制剂产生锥体外系反应。甚至不应用精神抑制剂时，单独应用SSRIS也会引起锥体外系反应。SSRIS不是直接阻滞多巴胺受体，而是通过一个多突触通道调节纹状体多巴肤的水平而使多巴胺活性下降。这也 Since the use of serotonin selective reuptake inhibitors (SSRIs), it has been reported that these agents sometimes promote the extrapyramidal reactions of neuroleptics. Even without the use of neuroleptic agents, SSRIS alone can cause extrapyramidal reactions. Instead of directly blocking dopamine receptors, SSRIS decreases dopamine activity by regulating the level of striatal dopaminergic in a multisynaptic canal. It also