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目的探讨该地区汉族、维吾尔族多发性骨髓瘤(MM)患者血清乳酸脱氢酶(LDH)、α-羟丁酸脱氢酶(HBDH)、超敏C反应蛋白(hs-CRP)的变化及其临床意义。方法对122例MM患者(实验组)血清进行免疫固定电泳,对实验组和40例健康体检者(健康对照组)血清采用速率法检测LDH和HBDH,采用胶乳增强免疫透射比浊法检测hs-CRP。结果免疫固定电泳分型:IgG型66例、IgA型19例、IgM型10例、轻链型27例;对于血清LDH、HBDH、hs-CRP水平,实验组明显高于健康对照组,且Ⅱ、Ⅲ期的MM患者明显高于Ⅰ期患者,差异均有统计学意义(P<0.05);轻链型较健康对照组3个指标水平均明显升高,差异有统计学意义(P<0.05);女性维吾尔族MM患者较健康对照组3个指标升高明显,且差异有统计学意义(P<0.05)。结论血清LDH、HBDH、hs-CRP水平,对该地区汉族、维吾尔族MM患者的病情判断和疗效监测有一定临床意义。
Objective To investigate the changes of serum lactate dehydrogenase (LDH), α-hydroxybutyrate dehydrogenase (HBDH) and high sensitivity C-reactive protein (hs-CRP) in Han and Uighur multiple myeloma patients in this area. Its clinical significance. Methods The serum of 122 patients with MM (experimental group) was subjected to immunostaining. LDH and HBDH were detected by the rate method in the serum of 40 healthy volunteers (experimental group) and the serum hs- CRP. Results The results of immunostaining showed that there were 66 cases of IgG, 19 cases of IgA, 10 cases of IgM and 27 cases of light chain. The levels of serum LDH, HBDH and hs-CRP in experimental group were significantly higher than those in healthy control group (P <0.05). The levels of three indexes in the light chain group were significantly higher than those in the control group (P <0.05), the level of MM in stage Ⅲ was significantly higher than that in stage Ⅰ ); The female Uygur MM patients increased significantly compared with the healthy control group three indicators, and the difference was statistically significant (P <0.05). Conclusions The levels of serum LDH, HBDH and hs-CRP have some clinical significance in judging the disease and monitoring the curative effect of MM in Han and Uygur nationality in this area.