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目的探讨干燥综合征合并肾小管酸中毒的临床特点,以便早期诊断、及时治疗、有效减少误诊误治。方法在总结我院诊治1例干燥综合征合并肾小管酸中毒基础上,分析干燥综合征肾损害的临床及病理特征。结果干燥综合征肾损害的病理改变主要为间质性肾炎,高lgG血症与dRTA之间存在一定的相关性,对于高lgG血症患者留意检查小管功能,尤其是小管的酸化功能。结论干燥综合征易合并肾脏损害,其中多数表现为肾小管酸中毒和并发骨软化症等肾性骨病的表现,合并肾小管酸中毒临床特点慢性高氯性代谢性酸中毒,伴有夜尿增多,多合并有高lgG血症,引起临床重视,早期诊断、及时治疗,改善患者远期预后。
Objective To investigate the clinical features of Sjogren’s syndrome combined with renal tubular acidosis for early diagnosis and timely treatment, which can effectively reduce misdiagnosis and mistreatment. Methods Based on the diagnosis and treatment of one case of Sjogren’s syndrome and renal tubular acidosis in our hospital, the clinical and pathological features of Sjogren’s syndrome were analyzed. Results The pathological changes of Sjogren’s syndrome renal damage were mainly interstitial nephritis. There was a certain correlation between hypergammaglobulinemia and dRTA. In patients with high lgGmia, attention should be paid to the tubule function, especially the tubulointerstitial function. Conclusion Sjogren’s syndrome is easily associated with renal damage, most of which manifest renal tubular acidosis and osteomalacia and other manifestations of renal osteodystrophy, combined with renal tubular acidosis clinical features chronic hyperchloric acid metabolic acidosis, accompanied by nocturia Increased, combined with high lgG hyperlipidemia, causing clinical attention, early diagnosis, timely treatment, improve long-term prognosis of patients.