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目的探讨健康男性青年服用卡维地洛后不同血药浓度下静息心电图P波间期最大值(Pmax)与用药前比较有无显著性变化,以对卡维地洛的抗心律失常作用机制提供依据。方法对20例健康男青年在服用卡维地洛20 mg前及服药后0.5、1、2、3、4、6、8、10、24 h分别测血药浓度,并做静息心电图,于12导联心电图测量P波间期最大值。结果 Pmax变化与血药浓度的变化没有明显相关性,且与用药前结果比较差异无统计学意义,(P>0.05)。结论卡维地洛对正常健康男性的Pmax可能无影响,从反面证实,它主要对有病理情况下的心脏病患者有抗心律失常作用。
Objective To investigate whether the Pmax of resting electrocardiogram (P wave) at different plasma concentrations in healthy male youth after taking carvedilol is significantly different from that before treatment, and its antiarrhythmic mechanism Provide evidence. Methods 20 healthy young men before taking carvedilol 20 mg and 0.5,1,2,3,4,6,8,10,24 h after taking drug concentration were measured, and resting ECG, at 12-lead electrocardiogram measured maximum P wave interval. Results The change of Pmax had no significant correlation with the change of plasma concentration, and there was no significant difference between before and after treatment (P> 0.05). Conclusion Carvedilol may not affect the Pmax of normal healthy men. On the contrary, it has been confirmed that it is mainly antiarrhythmic for heart disease patients under pathological conditions.