论文部分内容阅读
目的观察5%咪喹莫特乳膏预防二氧化碳(CO2)激光治疗后宫颈尖锐湿疣(CA)的复发情况和对人乳头瘤病毒(HPV)的清除情况。方法对94例宫颈CA(HPV阳性)患者先进行CO2激光治疗,再随机分为观察组(46例)和对照组(48例),观察组给予5%咪喹莫特乳膏涂布宫颈及阴道后穹窿,每周2次,共12周。随访24周。对照组在CA复发时只进行激光治疗。两组患者均在CO2激光治疗后第12周、第24周进行HPV复查。结果两组在术后第12周、24周的疣体复发情况比较差异有统计学意义(P均<0.05),观察组的复发率低于对照组。在12周及24周时观察组HPV清除率较对照组高,两者比较差异有统计学意义(P均<0.05)。结论在CO2激光治疗后,5%咪喹莫特乳膏能有效预防宫颈尖锐湿疣的复发,对HPV有良好的清除作用。
Objective To observe the recurrence of cervical condyloma acuminatum (CA) and the clearance of human papillomavirus (HPV) after 5% imiquimod cream in the prevention of carbon dioxide (CO2) laser treatment. Methods Ninety-four patients with cervical CA (HPV positive) were treated with CO2 laser before they were randomly divided into observation group (46 cases) and control group (48 cases). The observation group was given 5% imiquimod cream to coat the cervix and Vaginal posterior fornix, 2 times a week for a total of 12 weeks. Followed up for 24 weeks. The control group only performed laser treatment when the CA recurred. Both groups of patients underwent 12 weeks and 24 weeks after CO2 laser treatment for HPV review. Results There were significant differences in the recurrence of wart between the two groups at the 12th week and the 24th week (all P <0.05). The recurrence rate of the observation group was lower than that of the control group. The HPV clearance rate in observation group was higher than that in control group at 12 weeks and 24 weeks (P <0.05). Conclusion After CO2 laser treatment, 5% imiquimod cream can effectively prevent the recurrence of cervical condyloma acuminatum and has a good scavenging effect on HPV.