经典的方法是将麻风菌接种于小鼠足垫,并在6～12月期间作细菌计数,确定繁殖情况,以之作为测定麻风分枝杆菌活力的方法。但由于此法需时长,要大量动物,使之不宜于在治疗中作为评价每例病人的常规方法。测定菌量的细菌指数(BI)已用于评价对化疗的反应,但它不能测定杀死细菌的实际情况,而且下降缓慢。形态指数 The classical method is to inoculate the leprosy bacterium into the foot pad of the mouse and to count the bacteria during June to December to determine the reproduction as a measure of the viability of leprosy. However, because this method takes a long time and requires a large number of animals, it should not be used as a routine method for evaluating each patient in treatment. The bacterial index (BI) for determining the amount of bacteria has been used to evaluate the response to chemotherapy, but it has not been able to determine the actual condition that kills the bacteria and declines slowly. Morphological index