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目的探讨经颅多普勒超声监测脑血流动力学参数对早期发现多发性脑梗塞患者认知障碍的应用价值。方法对156例维吾尔族多发性脑梗塞(MI)患者进行经颅多普勒超声(TCD)、简易智力状况检查量表(MMSE)动态监测,每3个月监测1次,共24个月,对结果进行统计分析。结果多发性脑梗塞性痴呆(MID)发病率为25.0%(39/156),其中23例发生于随访的9个月后,占58.9%;随访中出现痴呆的患者的平均血流速度(Vm)降低,而搏动指数(PI)增加。与单纯MI组相比,两组Vm从9个月开始即显示出明显的差异,较MID的发生高峰提前约3个月。结论用TCD动态监测维吾尔族MI患者的脑血流动力学参数对早期发现多发性脑梗塞患者认知障碍有重要价值。
Objective To investigate the clinical value of transcranial Doppler ultrasound in the monitoring of cerebral hemodynamic parameters in the early detection of cognitive impairment in patients with multiple cerebral infarction. Methods TCD and MMSE were measured in 156 Uygur patients with multiple cerebral infarction and were monitored every 3 months for 24 months. Statistical analysis of the results. Results The incidence of multiple cerebral infarction dementia (MID) was 25.0% (39/156), of which 23 occurred after 9 months of follow-up, accounting for 58.9%. The average blood flow velocity of patients with dementia at follow-up ) Decreased, while pulsatility index (PI) increased. Compared with the MI group alone, two groups of Vm showed significant differences from the 9th month, about 3 months earlier than the MID peak. Conclusions The dynamic monitoring of cerebral hemodynamics in patients with Uygur MI with TCD is of great value in early detection of cognitive impairment in patients with multiple cerebral infarction.