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Objective: The aim of our study was to investigate the expression of p53, p57(Kip2) and CD68 in esophageal squamous cell carcinoma (ESCC) and their correlation with the biological behavior of ESCC. Methods: The protein expressions of p53, p57(Kip2) and CD68 were detected in 51 cases of ESCC with S-P immunohistochemical method. Results: The total positive rate of those proteins was p53 64.71%, CD68 58.82% and p57(Kip2) 45.09% respectively in ESCC. The positive expression rate of p57(Kip2) was significantly lower in the positive p53 of ESCC than in the negative p53 (P < 0.05). The positive expression rate of p57(Kip2) was significantly lower in the positive CD68 of esophageal squamous cell carcinoma than in the negative (P < 0.05). The positive expression of p53 and CD68 were related to differentiate and TNM of ESCC, but p57(Kip2) was not related to TNM (P > 0.05). Conclusion: There are significant negative correlations between p57(Kip2) and p53, CD68 protein expression and related to biological behavior. Multy predictors are better guide to patients than single predictor.
Objective: The aim of The study was to investigate the expression of p53, p57 (Kip2) and CD68 in esophageal squamous cell carcinoma (ESCC) and their correlation with the biological behavior of ESCC. Methods: The protein expressions of p53, p57 Results: The total positive rate of those proteins was p53 64.71%, CD68 58.82% and p57 (Kip2) 45.09% respectively in ESCC. The positive expression rate of p57 ( The positive expression rate of p57 (Kip2) was significantly lower in the positive CD68 of esophageal squamous cell carcinoma than in the negative (P <0.05) 0.05). The positive expression of p53 and CD68 were related to differentiate and TNM of ESCC, but p57 (Kip2) was not related to TNM (P> 0.05). Conclusion: There are significant negative correlations between p57 (Kip2) and p53, CD68 protein expression and related to bi ological behavior. Multy predictors are better guide to patients than single predictor.