Low standard oral anticoagulation therapy for Chinese patients with St.Jude mechanical heart valves

来源 :中华医学杂志(英文版) | 被引量 : 0次 | 上传用户:zj3132
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
Objective To study the efficacy of the low standard oral anticoagulation therapy following St Jude Medical (SJM) valve implantation for Chinese patients.Methods Totally 805 patients with a mean age of 42.70±11.09 years, enrolled into this study. Among them, 230 underwent aortic valve replacements (AVR), 381 mitral valve replacements (MVR), 189 double valve replacements (DVR) and 5 tricuspid valve replacememts (TVR). All patients received postoperative oral anticoagulation therapy based on a low standard of intational normalized ratio (INR, 2.0-2.5). Of the 805 patients, 710 were followed up for 0.25-13 years (a median, 4.15 years). Results Postoperatively, 17 adverse events occurred. Operative mortality was 2.11%. The most frequent cause of operative mortality was a low cardiac output. During follow-up, there were 47 anticoagulant-induced hemorrhages [1.59%/patient-year (pt-yr)], 10 cases of thromboembolism (0.34%/pt-yr), and 3 mechanical valve thromboses (0.19%/pt-yr). There were 44 late deaths and the linearized late mortality rates were 0.51%pt-yr. Estimates of actuarial survival for all patients at 5 and 10 years was 97.45% (0.70%) and 77.96% (17.44%), respectively.Conclusions A low target INR range of 2.0-2.5 is preferable for Chinese patients so as to reduce the severe bleeding complications in those with conventionally higher levels of INR. The long-term results were satisfactory in terms of the numbers of those who suffered thrombosis, embolism and bleeding.
其他文献
目的 提高家长护理早产儿水平、减少出院后疾病发生,提高早产儿生存质量.方法 采取讲解、交流、示范的健康教育等方式,对家长实施健康教育指导.结果 对家长实施健康教育指导
采用新型特殊设计的光学传输部件,将外部照明光源导入待测管道内部,同时将管道内壁图像导出,突破了传感器内置的传统工作模式,实现了测量传感器外置,满足了微细管道管内空间狭小的应用需求。同时,结合工业机器人运动平台,进一步构建了柔性在线测量系统,满足了不同工件中不同位姿分布的微细管道柔性测量需要。根据应用要求,首先在前期研究工作分析的基础上,完善了测量系统方案设计;对系统工作流程及核心问题进行了分析,并
为了更方便、简洁地使用本专业领域内的名词术语及其缩略语,本刊特公布公知公认的部分缩略语,作者在撰写文章时可以直接使用以下缩略语,而不必再注明其全称。未公布的名词术语,请按照如下规则进行缩写:原词过长(一般为超过4个汉字)且在文中多次出现者,若为中文缩略语可于第1次出现时写出全称,在括号内写出缩略语,如:卵巢上皮性癌(卵巢癌);若为外文缩略语可于第1次出现时写出中文全称,在括号内写出外文全称及其缩略
期刊
就哈密球团厂链箅机上生球爆裂严重现象进行了分析,认为风流系统不合理是造成该现象的主要原因。通过采取相应的改进措施,链箅机上生球爆裂现象得到有效遏制。 The serious
当花不摇树不动风车也静静地停在那里不转时,那些靠风力干活的咖啡工该如何工作呢?关于这个问题,也许研究人员搜肠刮肚也永远想不出好办法来,可是挪威一个小岛却想出了一个前
Objective To investigate whether coagulation factor Ⅶ (FⅦ) polymorphisms play a role in the pathogenesis of coronary artery disease (CAD) and/or myocardial in
控制连续大量流动物料的成分波动,保持成分稳定,是炼铁系统原燃料精料中的一个突出问题,对大宗原燃料进行分门别类管理和使用是稳定物料成分的有效措施之一。本文分析总结了