论文部分内容阅读
随着急性白血病有效化学治疗的发展,其缓解率得到提高,患儿生存期延长,其重要复发因素髓外浸润日益受到重视。白血病髓外浸润是白血病常见临床表现,不仅为治疗带来困难,也是白血病复发的高风险因素。白血病髓外浸润多见于中枢神经系统、睾丸,其次发生于纵膈、腮腺、牙龈、肾脏、皮肤、卵巢、眼、心脏、肺、肠道等,其机制复杂,受细胞因子严格调控,包括白血病细胞的趋化、黏附、迁移、降解基质、异地生存及抗凋亡等多
With the development of effective chemotherapy for acute leukemia, the remission rate is improved, the survival of children is prolonged, extramedullary infiltration of its important recurrence factor is increasingly valued. Leukemia extramedullary infiltration is a common clinical manifestations of leukemia, not only for the treatment of difficulties, but also a high risk factor for the recurrence of leukemia. Leukemia extramedullary infiltration is more common in the central nervous system, testis, followed by the mediastinum, parotid gingival, kidney, skin, ovary, eye, heart, lung, intestine, the mechanism is complex and strictly regulated by cytokines, including leukemia Cell chemotaxis, adhesion, migration, degradation of matrix, survival and anti-apoptosis in many places