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目的:探讨综合疗法对围绝经期综合征患者症状改善和血清雌激素水平的影响。方法:对68例围绝经期综合征患者进行心理干预和药物联合治疗3个月,比较治疗前后的血清雌激素水平及症状Kupperman评分。结果:68例患者血清E2由治疗前的(57.94±22.90)pmol/L升高至治疗后的(185.42±46.98)pmol/L,FSH和LH显著下降(P<0.01),临床症状明显改善,改良Kupperman评分显著好于治疗前(P<0.01)。结论:综合疗法可显著升高围绝经期综合征患者的血清雌激素水平,改善临床症状。
Objective: To investigate the effect of combination therapy on the improvement of symptoms and serum estrogen level in patients with perimenopausal syndrome. Methods: Sixty-eight patients with perimenopausal syndrome were treated with psychological intervention and drug combination therapy for 3 months. Serum estrogen level and Kupperman’s score before and after treatment were compared. Results: Serum E2 of 68 patients increased from (57.94 ± 22.90) pmol / L before treatment to (185.42 ± 46.98) pmol / L after treatment, FSH and LH decreased significantly (P <0.01) The modified Kupperman score was significantly better than before treatment (P <0.01). Conclusion: The combination therapy can significantly increase the level of serum estrogen in patients with perimenopausal syndrome and improve the clinical symptoms.