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目的观察伊曲康唑注射液治疗血液系统恶性肿瘤患者伴发真菌感染的临床疗效及安全性。方法选择浙江大学医学院附属第一医院血液科2004年2月至2005年4月住院恶性血液病患者51例。男35例、女16例,中位年龄42岁。确诊或拟诊真菌感染或经验性治疗使用伊曲康唑,剂量为:每次200mg,每12h1次;用2d后,每次200mg,每天1次,完成疗程7d以上评价疗效。完成者共49例,疗程为7～32d,中位数14d。结果伊曲康唑注射液临床总有效率59.2%,真菌清除率为71.4%。副反应中没有发现用药时寒战、发热等,以及胃肠道反应。肝功能异常发生率7.8%,肾功能损害发生率2%。结论伊曲康唑注射液抗菌谱较广,其注射液在治疗深部真菌感染中为高效药物,且药物安全性良好,但在使用时尚需监测肝功能。
Objective To observe the clinical efficacy and safety of itraconazole injection in treating patients with hematological malignancies complicated with fungal infection. Methods Fifty-one patients with hematologic malignancies were admitted to Department of Hematology, First Affiliated Hospital of Zhejiang University from February 2004 to April 2005. There were 35 males and 16 females, with a median age of 42 years. Diagnosed or suspected diagnosis of fungal infection or empirical treatment with itraconazole dose: each 200mg, every 12h1; with 2d, each 200mg, day 1, to complete the course of treatment for more than 7d evaluation of efficacy. A total of 49 cases completed, treatment for 7 ~ 32d, median 14d. Results Itraconazole injection clinical total effective rate 59.2%, fungal clearance rate was 71.4%. Side effects did not find medication chills, fever, etc., and gastrointestinal reactions. The incidence of abnormal liver function 7.8%, the incidence of renal damage 2%. Conclusion Itraconazole injection antibacterial spectrum is broad, its injection in the treatment of deep fungal infection is highly effective drugs, and drug safety is good, but in the use of the need to monitor liver function.