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目的探讨序贯血液净化治疗急性重度有机磷农药中毒的临床疗效。方法选取2012年4月至2015年4月符合诊断标准的急性重度有机磷农药中毒患者120例,依据治疗方案分为实验组和对照组,每组60例。对照组在常规治疗基础上行序贯血液灌流,实验组在常规治疗的基础上行序贯血液灌流及连续静脉-静脉血液滤过,比较两组治疗效果。结果实验组治愈率为95.0%,病死率为5.0%;对照组治愈率为86.7%,病死率为13.3%。实验组胆碱酯酶活性恢复、机械通气、住院时间及昏迷时间均短于对照组,差异有统计学意义(P<0.05)。结论急性重度有机磷农药中毒应用序贯血液净化治疗可有效提高临床治愈率,改善预后,值得临床推广应用。
Objective To investigate the clinical efficacy of sequential blood purification in acute severe organophosphorus pesticide poisoning. Methods A total of 120 patients with acute severe organophosphorus pesticide poisoning who met the diagnostic criteria from April 2012 to April 2015 were selected and divided into experimental group and control group according to the treatment plan, with 60 cases in each group. The control group received sequential hemoperfusion on the basis of conventional treatment. The experimental group received sequential hemoperfusion and continuous venovenous-venous hemofiltration on the basis of routine treatment. The therapeutic effects were compared between the two groups. Results The cure rate was 95.0% in experimental group and the case fatality rate was 5.0%. The cure rate in control group was 86.7% and the case fatality rate was 13.3%. The activity of cholinesterase in experimental group recovered, mechanical ventilation, hospitalization time and coma time were shorter than those in control group, the difference was statistically significant (P <0.05). Conclusion Acute severe organophosphorus pesticide poisoning sequential blood purification treatment can effectively improve the clinical cure rate and improve the prognosis, it is worthy of clinical application.