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1目的 探讨透析对糖尿病肾衰竭病人转化生长因子 (TGF- β1 )表达的影响。2方法 采用逆转录聚合酶链反应 (RT- PCR)半定量技术 ,对糖尿病肾衰竭不同治疗组病人外周血单个核细胞 (PBMC) TGF- β1 m RNA的表达进行检测。 3结果 糖尿病肾衰竭透析病人 TGF- β1 m RNA的表达明显高于对照组 (t=12 .5 30 ,P<0 .0 1) ,且血液透析病人 TGF- β1 m RNA的表达较腹膜透析病人高 (t=2 .134 ,P<0 .0 5 )。 4结论 血液透析可使糖尿病肾衰竭病人 TGF- β1 过度表达
1 Objective To investigate the effect of dialysis on the expression of transforming growth factor-β1 (TGF-β1) in diabetic patients with renal failure. 2 Methods Reverse transcription-polymerase chain reaction (RT-PCR) semi-quantitative technique was used to detect the expression of TGF-β1 mRNA in peripheral blood mononuclear cells (PBMCs) in patients with diabetic renal failure. 3 Results Diabetic renal failure dialysis patients with TGF-β1 m RNA expression was significantly higher than the control group (t = 12 .5 30, P <0.01), and hemodialysis patients TGF-β1 m RNA expression than peritoneal dialysis patients High (t = 2.134, P <0.05). 4 Conclusion Hemodialysis diabetic patients with TGF-β1 overexpression