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目的:探讨Cortactin(CTTN)蛋白在结直肠癌组织中的表达变化及其临床意义。方法:采用免疫组织化学法检测100例结直肠癌组织和癌旁正常组织中CTTN蛋白的表达情况,分析CTTN蛋白的表达变化与结直肠癌患者临床病理指标及预后的关系。结果:CTTN蛋白在结直肠癌组织中的阳性表达率为58%,显著高于癌旁正常组织的6%(P<0.01)。CTTN蛋白(<0.05)阳性表达率在不同的T分期(浸润深度)间的差异有统计学意义,而与患者的性别、年龄、肿瘤原发部位、肿瘤大小和淋巴结转移均无显著相关(P>0.05)。生存分析的结果显示,CTTN阳性患者的预后差于CTTN阴性患者(P=0.014)。结论:CTTN蛋白在结直肠癌中表达增加,并与结直肠肿瘤的浸润深度有关,可能作为结直肠癌预后判断的指标。
Objective: To investigate the expression of Cortactin (CTTN) in colorectal cancer and its clinical significance. Methods: The expression of CTTN protein in 100 cases of colorectal cancer tissues and adjacent normal tissues was detected by immunohistochemistry. The relationship between CTTN protein expression and the clinicopathological parameters and prognosis of colorectal cancer was analyzed. Results: The positive expression rate of CTTN protein in colorectal cancer tissues was 58%, which was significantly higher than that in 6% normal tissues (P <0.01). The positive expression rate of CTTN protein (<0.05) in different T stages (depth of invasion) was statistically significant, but not with the patient’s gender, age, tumor location, tumor size and lymph node metastasis (P > 0.05). Survival analysis showed that the prognosis of CTTN-positive patients was worse than that of CTTN-negative patients (P = 0.014). Conclusion: The expression of CTTN protein is increased in colorectal cancer and correlates with the depth of invasion of colorectal cancer, which may be used as an indicator of the prognosis of colorectal cancer.