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目的探讨雄激素受体(AR)与新疆地区的汉族与维吾尔族三阴性乳腺癌(TNBC)患者临床病理特征的关系。方法回顾性分析2012年12月至2016年12月期间就诊于新疆医科大学第一附属医院的汉族与维吾尔族TNBC患者的临床病理资料,提取AR表达情况及患者的临床病理特征资料,结果采用SPSS 19.0进行统计分析。结果共收集到178例TNBC患者的临床病理资料,其中汉族127例,维吾尔族51例在178例TNBC患者中AR表达阳性率为21.3W0(38/178),AR阳性表达与TNBC患者的增殖细胞核抗原(Ki-67)表达有关(X~2=15.196,P<0.001),而与TNBC患者的民族(x~2=0.203,P=0.688)、年龄(x~2=0.221,P=0.715)、肿瘤大小(A=0.047,P=0.855)、组织学分级(AY=0.001,P=1.000)及淋巴结状态(x~2=0.874,P=0.354)均无关,且在新疆地区的维族和汉族TNBC患者的临床病理特征比较差异均无统计学意义(P>0.05)。结论在新疆地区的TNBC患者中,AR阳性表达与Ki-67表达有关,而维族与汉族TNBC患者间的临床病理特征无差异。
Objective To investigate the relationship between androgen receptor (AR) and the clinicopathological features of Han and Uygur patients with triple negative breast cancer (TNBC) in Xinjiang. Methods The clinical and pathological data of Han and Uygur TNBC patients who visited the First Affiliated Hospital of Xinjiang Medical University from December 2012 to December 2016 were retrospectively analyzed. The expression of AR and the clinicopathological features of the patients were extracted. The results were analyzed using SPSS. 19.0 for statistical analysis. Results A total of 178 cases of TNBC were collected for clinical and pathological data, among which 127 were Han Chinese, 51 were Uygur and 178 were TNBC. The positive rate of AR expression was 21.3W0 (38/178). AR positive expression was associated with proliferating cell nucleus in TNBC patients. The expression of antigen (Ki-67) was related (X~2=15.196, P<0.001), while the ethnicity of patients with TNBC (x~2=0.203, P=0.688), age (x~2=0.221, P=0.715) The tumor size (A=0.047, P=0.855), histological grade (AY=0.001, P=1.000), and lymph node status (x~2=0.874, P=0.354) were irrelevant, and Uygur and Han in Xinjiang There was no significant difference in the clinical pathological features of TNBC patients (P>0.05). Conclusion In the TNBC patients of Xinjiang region, the positive expression of AR is related to the expression of Ki-67, but there is no difference in the clinicopathological features between the Uygur and Han TNBC patients.