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A Review] The biological characteristics of viral L6565 leukemia cell clone were as follows: (1) The chromosome counts varied 38～114 , and stem cells were 42; (2) Virus particles type A and type C found in the cytoplasm of clone cells; (3) X-C assays were positive, c- myc and c- fos gene overexpressed in clone cells; (4) Differential markers CD4, CD8, CD45R were negative, CD45RO λ were positive; (5) The supernatant of clone cells could induce T or B lymphocytic leukemia/lymphoma and granulocytic leukemia in SSB strain mice. The leukemogenic effect of concentrate supernatant was stronger than non-concentrate supernatant( P< 0.05); (6) The antisense of the c- myc gene induced low expression of c- myc protein, and inhibited the growth of viral L6565 clone cells.
A Review] The biological characteristics of viral L6565 leukemia cell clone were as follows: (1) The chromosome counts varied from 38 to 114, and stem cells were 42; (2) Virus particles type A and type C found in the cytoplasm of clone cells (4) Differential markers CD4, CD8, CD45R were negative, CD45RO λ were positive; (5) The supernatant of clone cells could induce T or B lymphocytic leukemia / lymphoma and granulocytic leukemia in SSB strain mice. The leukemogenic effect of concentrate supernatant was stronger than non-concentrate supernatant (P <0.05); (6) The antisense of the c-myc gene induced low expression of c - myc protein, and inhibited the growth of viral L6565 clone cells.