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目的探讨中晚期梅毒患者医院感染的常见病原菌分布及血清学改变,为临床诊治提供参考依据。方法选取2009年4月-2014年4月医院收治的中晚期梅毒患者213例,将其中发生医院感染患者109例作为观察组,未发生医院感染患者104例作为对照组;取两组患者血液进行实验室检查,对其临床资料进行比较,数据采用SPSS 13.0软件进行统计分析。结果 109例医院感染患者共检出病原菌138株,以革兰阳性菌为主,共86株占62.32%;对照组患者IL-2、IL-10和IL-12分别为(97.15±10.54)(122.53±11.27)ng/L和(83.76±8.95)ng/L,观察组患者分别为(108.20±11.09)(117.04±9.27)ng/L和(63.81±6.19)ng/L,两组比较差异有统计学意义(P<0.05),两组患者IL-10水平差异无统计学意义。结论引起中晚期梅毒患者医院感染的病原菌以革兰阳性菌为主,经验性用药时可以此作为参考;而医院感染的患者与其他中晚期梅毒患者相比血清学检查存在差异,可以作为诊断参考。
Objective To investigate the distribution of common pathogens and serological changes of nosocomial infections in patients with middle and late syphilis, and to provide a reference for clinical diagnosis and treatment. Methods Totally 213 middle and late syphilis patients admitted from April 2009 to April 2014 in our hospital were selected as the observation group and 109 patients without nosocomial infection as the observation group. Blood was taken from both groups Laboratory tests, their clinical data were compared, the data using SPSS 13.0 software for statistical analysis. Results A total of 138 pathogenic bacteria were detected in 109 cases of hospital-acquired infections, of which, Gram-positive bacteria were the major pathogens, accounting for 62.32% of all cases. The levels of IL-2, IL-10 and IL-12 in the control group were 97.15 ± 10.54 122.83 ± 11.27 ng / L and 83.76 ± 8.95 ng / L, respectively. The difference between the two groups was (108.20 ± 11.09) (117.04 ± 9.27) ng / L and (63.81 ± 6.19) ng / L respectively Statistical significance (P <0.05), the two groups of patients with no significant difference in IL-10 levels. Conclusions The pathogenic bacteria causing nosocomial infection in patients with middle and late syphilis are mainly Gram-positive bacteria, which may serve as a reference for empirical drug use. However, there are differences in serological tests between patients with nosocomial infection and other patients with advanced or intermediate syphilis and can be used as a reference for diagnosis .