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目的 :应用枢复宁改良方案预防高剂量顺铂所致的胃肠道反应 ,寻求高效而经济的止吐方案。方法 :将应用高剂量顺铂的 80例患者随机分为 3组 :A组应用单次枢复宁 +地塞米松控制急性期呕吐反应 ,枢复宁控制延缓期呕吐反应 ;B组应用多剂枢复宁 +地塞米松控制急性期呕吐反应 ,枢复宁控制延缓期呕吐反应 ;C组应用单次枢复宁 +地塞米松控制急性期呕吐反应 ,胃复安控制延缓期呕吐反应。结果 :对急性期呕吐反应的预防 ,单次枢复宁组的有效率为 94 5 % ,与多次枢复宁组的 92 %无显著性差异 (P >0 0 5 ) ,对延缓期呕吐反应的预防枢复宁组的有效率为 76 6 % ,胃复安组的有效率为 78 8% ,二者亦无显著性差异 (P >0 0 5 )。结论 :应用单次枢复宁预防急性期呕吐反应 ,应用胃复安预防延缓期呕吐反应 ,既高效又经济 ,值得推广应用
OBJECTIVE : To apply a modified shufuning regimen to prevent gastrointestinal reactions caused by high doses of cisplatin and to seek an efficient and economical antiemetic regimen. Methods: 80 patients with high doses of cisplatin were randomly divided into 3 groups: Group A was treated with sulfasalpone plus dexamethasone to control acute vomiting, and Shufuing was used to control delayed vomiting; Group B was given multiple doses. Shufuning + dexamethasone control acute vomiting reaction, Shufuning control anaesthesia delayed vomiting; C group use a single cis Fu Ning + dexamethasone to control acute vomiting reaction, metoclopramide control delayed vomiting reaction. Results: For the prevention of vomiting in acute stage, the effective rate of sulfidofamine group was 94.5%, and there was no significant difference (P > 0.05) between the sevoflurane group and the group. The effective rate of prevention of the reaction in the Shufuning group was 76.6%, and the effective rate of the metoclopramide group was 788%. There was no significant difference between the two groups (P > 0 05). Conclusion : Application of sulfamicin to prevent vomiting in acute phase and application of metoclopramide to prevent delayed vomiting are effective and economical. It is worth popularizing and applying.