蛋白激酶 C(protein kinase C,PKC)为一类蛋白质的磷酸化激酶,在各种生命活动中发挥重要作用。蛛网膜下腔出血后多种致痉挛物质(如内皮素和氧和血红蛋白等)增多和一氧化氮生成减少均可使平滑肌细胞PKC异常激活,活化的PKC通过对激动蛋白肌丝相关蛋白和K~+通道等的磷酸化,同时还可通过激活蛋白酪氨酸激酶和丝裂素活化蛋白激酶,使脑动脉平滑肌持续收缩,导致迟发性脑血管痉挛的形成。 Protein kinase C (PKC) is a type of protein phosphorylation kinase that plays an important role in various life activities. Subarachnoid hemorrhage after a variety of induced spastic substances (such as endothelin and oxygen and hemoglobin, etc.) increased and decreased production of nitric oxide can make smooth muscle cell PKC abnormal activation of PKC through the activation of the protein myosin and K ~ + Channel phosphorylation, but also by activating protein tyrosine kinase and mitogen-activated protein kinase, continuous contraction of cerebral artery smooth muscle, leading to the formation of delayed cerebral vasospasm.