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胃肠激素是调节机体消化系统生理和病理活动的重要因素,哺乳类动物的胃肠激素基本相似,而豚鼠具有独特的胃肠激素,氨基酸组成和排列均与其它哺乳动物明显相异。由51个氨基酸组成的胰岛素在大多数哺乳动物中,至多有4个氨基酸差异,而豚鼠与猪的胰岛素有17个氨基酸相异。猪、牛和人具有相同化学结构的胰高糖素,而豚鼠的胰高糖素却有5个氨基酸不同。豚鼠的胃泌素、胆囊收缩素和血管活性肠肽与其它哺乳动物也都有明显差异。一、胃泌素(gastrjn)胃泌素是1905年由 Edkins 发现的一种能刺激胃酸分泌的多肽激素,由胃窦部的 G 细胞分泌。1964年首先被 Gregory 和 Tracy 从猪的胃窦组织中提取并纯化了由17个氨基酸组成的小胃泌素 G17;以后又发现了由34个氨基酸组成的大胃泌素 G34,并陆续从其它的哺
Gastrointestinal hormone is an important factor in the regulation of the physiological and pathological activities of the digestive system. The gastrointestinal hormones of mammals are basically similar, while the guinea pigs have unique gastrointestinal hormones. Their amino acid composition and arrangement are obviously different from those of other mammals. Insulin, consisting of 51 amino acids, has at most four amino acid differences in most mammals, while guinea pigs and pigs have 17 different amino acids. Pig, cow and human have the same chemical structure of glucagon, guinea pig glucagon 5 amino acids are different. Guinea pig gastrin, cholecystokinin and vasoactive intestinal peptide and other mammals also have significant differences. Gastrin (gastrjn) Gastrin is a polypeptide hormone that stimulates gastric acid secretion discovered by Edkins in 1905 and secreted by G cells in the antrum. In 1964, firstly, Gregory and Tracy extracted and purified the small gastrin G17 consisting of 17 amino acids from the porcine sinus tissue. Later, 34-amino-acid gastrin G34 was found, and one after another The feed