颅内感染是严重的感染之一,其预后不良,因此如何合理应用抗生素,选择合适的给药途径及能否最大限度使感染灶内达到有效药物浓度是治疗的关键环节。1　颅内感染来源1.1　副鼻窦及乳突感染的蔓延　由于中耳炎、乳突炎或副鼻窦炎症侵蚀骨壁或经过板障血管桥静脉等感染血栓,波及邻 Intracranial infection is one of the serious infections and its prognosis is poor. Therefore, it is a key link in the treatment of how to use antibiotics reasonably, how to choose proper route of administration, and whether to maximize effective concentration of drug in the lesion. 1 source of intracranial infection 1.1 paranasal and mastoid infection spread due to otitis media, mastoiditis or paranasal sinusitis erosion of the bone wall or bridge through the platelet bridge vein infection thrombosis, spread to neighboring