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目的观察舍曲林联合心理干预对青少年抑郁症的治疗效果。方法青少年抑郁症患者100例,随机分为观察组和对照组,每组各50例。对照组口服舍曲林50 mg/d,连续服用12周;观察组在对照组的基础上进行心理干预12周;比较两组干预前后汉密尔顿抑郁量表(HAMD)、汉密尔顿焦虑量表(HAMA)、90项症状量表(SCL-90)评分。采用SPSS 19.0统计软件。计量资料以(xˉ±s)表示,比较采用t检验。P<0.05为差异有统计学意义。结果观察组和对照组治疗后HAMD、HAMA、SCL-90评分分别为(4.32±1.84)分和(11.76±3.65)分,(2.47±1.18)分和(9.15±2.05)分,(95.86±12.63)分和(140.25±33.30)分,均明显低于治疗前(P均<0.01),观察组治疗后降低更为明显(P均<0.01)。结论舍曲林联合心理干预可有效改善青少年抑郁症症状。
Objective To observe the effect of sertraline combined with psychological intervention on adolescent depression. Methods 100 cases of adolescent depression were randomly divided into observation group and control group, 50 cases in each group. The control group received sertraline 50 mg / d for 12 weeks. The observation group received psychological intervention for 12 weeks on the basis of the control group. The Hamilton Depression Inventory (HAMD), Hamilton Anxiety Inventory (HAMA) , 90 symptom scales (SCL-90) score. Using SPSS 19.0 statistical software. Measurement data to (xˉ ± s) said, compared with t test. P <0.05 for the difference was statistically significant. Results The scores of HAMD, HAMA and SCL-90 in the observation group and the control group after treatment were (4.32 ± 1.84) points and (11.76 ± 3.65) points, (2.47 ± 1.18) points and (9.15 ± 2.05) points respectively, (95.86 ± 12.63 ) Points and (140.25 ± 33.30) points were significantly lower than those before treatment (all P <0.01), and the observation group was more obvious after treatment (P <0.01). Conclusion Sertraline combined with psychological intervention can effectively improve the symptoms of depression in adolescents.