论文部分内容阅读
目的研究严重急性呼吸综合征(severeacuterespiratorysyndrome,SARS)患者康复期肺功能状态。方法随访康复出院的SARS患者89例,了解其症状、体征和并发症,测定肺功能。并对肺功能各项指标与临床指标作相关性分析。结果复查的时间距离发病时间平均为(2.90±0.44)个月(1.8～4.2个月),距离出院时间为(1.75±0.53)个月(0.5～3.4个月)。48例(53.9%)存在肺功能异常,多数为轻度异常,其中,单纯弥散障碍38例(42.7%),弥散障碍合并限制性通气功能障碍7例(7.9%),弥散障碍合并阻塞性通气功能障碍1例,单纯限制性通气功能障碍1例,单纯1秒钟呼气容积(forcedexpiratoryvolumeinthefirstsecond,FEV1)下降1例。病程中有呼吸困难症状和康复期胸部CT异常者一氧化碳弥散量(diffusioncapacityforcarbonmonoxide,DLCO)和肺总量(totallungcapacity,TLC)下降更明显。结论SARS患者康复期存在轻度的肺功能损害,以弥散障碍为主,其次是限制性通气功能障碍。
Objective To study the pulmonary function status during convalescence in patients with severe acute respiratory syndrome (SARS). Methods Eighty-nine SARS patients were discharged from hospital for follow-up. Their symptoms, signs and complications were observed and lung function was measured. And lung function indicators and clinical indicators for the correlation analysis. Results The time to reviewing was 2.90 ± 0.44 months (1.8 to 4.2 months) and 1.75 to 0.53 months (0.5 to 3.4 months) after discharge. Forty-eight patients (53.9%) had abnormal lung function, most of them were mild abnormalities. Thirty-eight patients (42.7%) had diffuse dysfunction alone, seven patients (7.9%) had diffuse dysfunction combined with restrictive ventilatory dysfunction, 1 case of dysfunction, 1 case of simple restrictive ventilation dysfunction and 1 case of decrease of FEV1 in 1 second. Dyspnea for carbon monoxide (DLCO) and total lung capacity (TLC) were more obvious in patients with dyspnea and congenital chest CT during convalescence. Conclusions There is mild pulmonary dysfunction during the convalescent phase in patients with SARS, mainly with diffuse disorder, followed by restrictive ventilatory dysfunction.