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目的:调查粤北山区瑶族地区女性人乳头状瘤病毒(HPV)感染状况和基因亚型分布。方法:采用亚能基因芯片分型检测技术对粤北山区瑶族地区600名妇女进行HPV分型检测,计算人群感染率,并对HPV亚型及年龄分布进行分析。结果:HPV阳性共79例,阳性率为13.2%;23种亚型中共有14种高危型HPV亚型被检出,高危型HPV阳性共68例,阳性率为11.3%,感染率最高依次为HPV58,16,52,68;高危型HPV检测阳性者中,单一型别感染率占高危型HPV感染的73.5%(50/68),复合感染率为26.5%(18/68)。HPV感染在25-29岁间及55岁后出现双峰,不同年龄段妇女高危型HPV感染率差异无统计学意义(P>0.05)。结论:粤北山区瑶族地区妇女HPV感染率较高,HPV58,16,52,68亚型是最主要的感染亚型,高危型HPV感染以单一型别感染为主,所有年龄阶段都有HPV感染高风险,应定期进行宫颈癌筛查。
Objective: To investigate the status of human papilloma virus (HPV) infection and the distribution of gene subtypes in the Yaobei mountainous area of northern Guangdong. Methods: The genotypes of subtypes and age distributions of HPV in 600 mountainous Yao people in northern Guangdong were detected by subgenotype DNA microarray. RESULTS: A total of 79 HPV positive cases were found, with a positive rate of 13.2%. A total of 14 high-risk HPV subtypes were detected in 23 subtypes. A total of 68 high-risk HPV positive cases were found, the positive rate was 11.3%. The highest infection rates were HPV58,16,52,68; high-risk HPV test positive, the single type infection rate of high-risk HPV infection accounted for 73.5% (50/68), the composite infection rate was 26.5% (18/68). There was a bimodal peak of HPV infection between 25-29 years old and 55 years old. There was no significant difference in the infection rate of high-risk HPV between women of different ages (P> 0.05). Conclusion: The prevalence of HPV infection is higher in Yao tribe in mountain area of northern Guangdong, HPV58, 16, 52 and 68 subtypes are the main subtypes of infection. High-risk HPV infection is predominant in single-type infection and HPV infection is found in all age groups High-risk, cervical cancer screening should be conducted regularly.