实验证实,顺铂在人体中枢神经系统内的分布浓度,使其适于作为脑转移癌的放疗增敏剂。放疗和顺铀同时应用,对乏氧细胞可能既有放疗增敏,又有抑制其损伤修复过程之功用。一系列的CT扫描又可对脑转移癌的疗效作出客观的评价。本文报告自1985年5月至1986年5月对13例脑转移癌病人同时应用放疗和顺铂治疗的效果及其毒性。 Experiments confirmed that the distribution concentration of cisplatin in the human central nervous system makes it suitable as a radiotherapy sensitizer for brain metastases. The simultaneous application of radiotherapy and cis-uranium may have both radiotherapy sensitization and inhibition of injury repair process for hypoxic cells. A series of CT scans can also provide an objective assessment of the efficacy of metastatic brain cancer. This article reports the efficacy and toxicity of simultaneous radiotherapy and cisplatin in 13 patients with metastatic brain cancer from May 1985 to May 1986.