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目的:观察综合干预法治疗代谢综合征(MS)及动脉僵硬度的效果。方法:选择MS 100例,随机分为观察组和对照组各50例。观察组采取健康教育、饮食运动干预、规范用药等综合干预法进行治疗;对照组仅用药物治疗。1年后,比较两组臂踝脉搏波速度(baPWV)、体质指数(BMI)、收缩压(SBP)、舒张压(DBP)、空腹血糖(FBG)、餐后2h血糖(P2hPG)、低密度脂蛋白(LDL)、三酰甘油(TG)等指标的变化。结果:观察组治疗后baPWV、BMI、SBP、FBG、P2hPG、LDL和TG等水平显著低于治疗前(P<0.05);与对照组治疗后比较,差异显著(P<0.05)。多元逐步回归分析结果显示,SBP、FBG是影响baPWV的独立危险因素。结论:综合干预法能有效控制MS,减缓动脉硬化的进展。
Objective: To observe the effect of comprehensive intervention on metabolic syndrome (MS) and arterial stiffness. Methods: 100 cases of MS were selected and randomly divided into observation group and control group, 50 cases each. Observation group to take health education, diet and exercise intervention, standardized medication and other comprehensive intervention for treatment; control group only with drug treatment. One year later, the bPWV, BMI, SBP, DBP, FBG, P2hPG, low density Lipoprotein (LDL), triglyceride (TG) and other indicators of change. Results: The levels of baPWV, BMI, SBP, FBG, P2hPG, LDL and TG in the observation group were significantly lower than those before treatment (P <0.05), but significantly different from those in the control group after treatment (P <0.05). Multiple stepwise regression analysis showed that SBP and FBG were independent risk factors for baPWV. Conclusion: Comprehensive intervention can effectively control MS and slow down the progress of atherosclerosis.