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目的探讨血清降钙素原(PCT)定量测定在新生儿血流感染诊断中的临床价值。方法选取2014年1月-2014年12月本院新生儿病房收治的血培养阳性患儿82例,作为血流感染组;选取同一时段新生儿血培养阴性患儿53例,作为非血流感染组。用SPSS 19.0软件比较血流感染组和非血流感染组血清PCT水平差异,同时绘制ROC曲线,评估血清PCT水平在新生儿血流感染诊断中的应用价值。结果新生儿血流感染组和非血流感染组之间血清PCT水平差异具有统计学意义(P<0.01),ROC曲线面积为0.826,以0.445 ng/ml作为诊断的cut-off值时,血清PCT水平诊断新生儿血流感染的灵敏度为87.8%,特异度为71.7%。结论血清PCT定量测定可作为新生儿血流感染较有价值的诊断指标。
Objective To investigate the clinical value of serum procalcitonin (PCT) quantitative determination in the diagnosis of neonatal bloodstream infection. Methods From January 2014 to December 2014, 82 children with positive blood culture in our hospital were selected as the bloodstream infection group. Fifty-three children with negative blood culture in the same period were selected as non-bloodstream infection group. SPSS 19.0 software was used to compare the difference of serum PCT between the bloodstream infection group and the non-bloodstream infection group, meanwhile, the ROC curve was drawn to evaluate the value of serum PCT in the diagnosis of neonatal bloodstream infection. Results There was a significant difference in serum PCT levels between neonates with bloodstream infection and non-bloodstream infection (P <0.01). The ROC curve area was 0.826. When the cut-off value was 0.445 ng / ml, serum PCT sensitivity of diagnosis of neonatal bloodstream infection was 87.8%, specificity was 71.7%. Conclusion Quantitative determination of serum PCT can be used as a more valuable diagnostic indicator of neonatal bloodstream infection.