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近年来,大量实验研究证明,巨噬细胞在矽肺的发病过程中起着十分重要的作用,用克矽平治疗猴矽肺,肺泡巨噬细胞显著增多,吞噬反应十分活跃,这个吞噬反应包括:吞噬细胞对石英微粒的吞噬和石英微粒对细胞的毒作用,它是矽肺发病的基础,也是寻找矽肺防治药物必须考虑的因素之一,目前报道的体外实验资料较多,为获取体内的实验资料,我们利用小白鼠进行实验,测定腹腔液中酸性磷酸酶(下称 ACP)的活性,观察石英微粒对腹腔吞噬细胞的毒性和克矽平对吞噬细胞的保护作用。
In recent years, a large number of experimental studies have shown that macrophages play a very important role in the pathogenesis of silicosis. Treatment of monkey silicosis with kesi-ping significantly increases the number of alveolar macrophages and phagocytosis, which includes phagocytosis Cells of quartz phagocytosis and quartz particles on the cell toxicity, it is the basis of silicosis, silicosis is also looking for drugs to consider one of the factors that have been reported in vitro experimental data more, in order to obtain experimental data in vivo, We use mice to experiment, determine the activity of acid phosphatase (hereinafter referred to as ACP) in peritoneal fluid, to observe the toxicity of quartz particles on peritoneal phagocytes and the protective effect of g-silicon on phagocytes.