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目的讨论乳腺癌组织中雌孕激素受体(ER、PR)的表达与腋窝淋巴结转移、年龄、及临床组织病理学类型的关系。方法运用免疫组化法用S-P试剂盒对我院随机抽取的260例乳腺癌患者肿瘤组织ER、PR的表达进行研究。结果将患者按[ER(+)PR(+),ER(-)PR(+),ER(-)PR(-),ER(+)PR(-)]分为四组,分析发现四组乳腺癌患者腋窝淋巴结转移率分别为21.3%、75.6%、69.2%、79.6%(P<0.05)。不同乳腺癌的组织学类型中ER、PR的表达没有统计学区别(P>0.05)。年龄分析发现ER(+)PR(+)组在40岁￣55岁的占86%,而其他三组的年龄主要分布在55岁以上和40岁以下占92%、89%、90%(P<0.05)。肿瘤直径<3cm在ER(+)PR(+)组占83%与其他三组(13%15%12%)有统计学差异(P<0.05)。结论我们研究发现乳腺癌组织中ER、PR与腋窝淋巴结转移及患者的年龄分布、肿瘤大小密切相关,而与肿瘤的组织学类型无相关性。
Objective To investigate the relationship between the expression of estrogen and progesterone receptor (ER, PR) and axillary lymph node metastasis, age, and histopathological types in breast cancer. Methods The expression of ER and PR in tumor tissue of 260 breast cancer patients randomly selected from our hospital by immunohistochemistry method with S-P kit was studied. Results The patients were divided into four groups by [ER (+) PR (+), ER (-) PR (+), ER (-) PR (-) and ER (+) PR Axillary lymph node metastasis rates in breast cancer patients were 21.3%, 75.6%, 69.2% and 79.6%, respectively (P <0.05). The expression of ER and PR in different histological types of breast cancer showed no statistical difference (P> 0.05). Age analysis found that the ER (+) PR (+) group was 86% at the age of 40 to 55 years and the other three groups were mostly older than 55 and 92%, 89%, and 90% at age 40 <0.05). The tumor size of <3 cm was 83% in the ER (+) PR (+) group and 13% (15% 12%) in the other three groups (P <0.05). Conclusion Our study found that ER, PR and axillary lymph node metastasis in patients with breast cancer and age distribution, tumor size are closely related, but not with the histological type of tumor.