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目的:调查2012年河北省抑郁症患者药物使用情况,为临床应用提供依据.方法:以2012年7月2-9日河北省11市各级精神卫生机构的门诊或住院抑郁症患者为调查对象,采用自制调查问卷调查一般资料及药物使用情况,以国际疾病和相关健康问题统计分类第十版(ICD-10)标准对患者进行诊断.结果:共调查抑郁症患者452名,其中门诊患者139名(30.8％),住院患者313名(69.2％),男性159名(35.2％),女性293名(64.8％);年龄15～81(46.10±14.36)岁;药物使用前3位为帕罗西汀、文拉法辛、舍曲林;联合2种抗抑郁药者27名(6％),且多为2种不同作用机制药物.结论:河北省2012年抗抑郁药使用基本合理,其中新型抗抑郁药为一线用药.“,”Objective:To investigate the drug use of patients with depression in Hebei province in 2012,and provide evidence for clinical application.Methods:During July 2-9th,2012,choosing outpatients or hospitalized patients with depression from all levels of mental health institutions that locate in 11 cities in Hebei province as the respondents.Using the self-made questionnaire to investigate the general information and drug use.Using the 10th edition of the international classification of diseases and related health problems(ICD-10)criteria to diagnose patients.Results:A total of 452 patients with depression were involved in the research,including 139 outpatients (30.8 ％),313 inpatients(69.2 ％),159 males(35.2％),293 females(64.8％).Age 15 ～ 81,average(46.1 ± 14.36) yeas.The‘first 3 place of drug use were Pa Rossi Dean,Venlafaxine,Seculin,27 (6 ％) patients combined 2 antidepressants,which were 2 different mechanisms of drug.Conclusion:The use of antidepressants in Hebei province in 2012 is basically reasonable,among which the new antidepressants are first-line drugs.