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本文分析了有关乳腺癌的两个假设.一是乳腺受到高浓度的雌激素的刺激患乳腺癌的危险性较高,二是高频率的不排卵的月经周期与患乳腺癌的危险有关.病例组选自美国大波士顿和旧金山海湾地区医院绝经期前的、并经组织学证实了的乳腺癌患者.这些患者术后或放疗后至少六个月未接受过化疗,且未患已知的其他肿瘤.对照组,在波士顿是健康的、非住院的妇女;在旧金山非妇科的住院妇女.病例与对照相配,年龄相差不超过5岁,经产情况一样.全部研究对象均为50岁以下的白种人,研究前24
This article analyzes two hypotheses about breast cancer: First, the risk of breast cancer is higher for breasts that are stimulated by high levels of estrogen, and second, the high frequency of anovulatory menstrual cycles is associated with the risk of developing breast cancer. The group was selected from premenopausal and histologically confirmed breast cancer patients in Greater Boston and San Francisco Bay Area hospitals who had received no chemotherapy after surgery or at least six months after radiotherapy and did not have other known The control group, a healthy, non-hospitalized woman in Boston, a non-gynecological in-hospital woman in San Francisco, matched the controls with a difference in age of less than 5 years, as was the case for all births, and all subjects were under 50 years of age Caucasian, pre-study 24