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目的探讨鼓膜置管术与鼓室注药治疗鼻咽癌放疗后分泌性中耳炎的临床疗效。方法 2010年4月至2012年1月间收治的鼻咽癌放疗后分泌性中耳炎患者128例,按治疗方式分为对照组(n=64)和试验组(n=64)。对照组采用盐酸氨溴索鼓室注药,试验组采用鼓膜置管术。比较两组患者的临床疗效、言语频率及并发症发生率。结果对照组和试验组患者的治疗总有效率分别为65.6%和87.5%,试验组患者的疗效明显优于对照组,差异有统计学意义(χ2=4.267,P<0.05)。对照组和试验组患者的并发症发生率分别为50.0%和15.6%,试验组患者的并发症发生率明显低于对照组,差异有统计学意义(χ2=8.576,P<0.05)。试验组患者的言语频率明显低于对照组,差异有统计学意义(t=3.202,P<0.05)。结论采用鼓膜置管术治疗鼻咽癌放疗后分泌性中耳炎的临床疗效优于鼓室注药。
Objective To investigate the clinical effects of tympanic membrane catheterization and tympanic injection in the treatment of secretory otitis media after radiotherapy of nasopharyngeal carcinoma. Methods 128 patients with secretory otitis media after nasopharyngeal carcinoma treated from April 2010 to January 2012 were divided into control group (n = 64) and experimental group (n = 64) according to the way of treatment. The control group received ambroxol hydrochloride intramuscular injection, and the experimental group received tympanic membrane catheterization. The clinical efficacy, speech frequency and complication rate were compared between the two groups. Results The total effective rates of the control group and the experimental group were 65.6% and 87.5%, respectively. The curative effect of the experimental group was obviously better than that of the control group (χ2 = 4.267, P <0.05). The complication rates in the control group and the experimental group were 50.0% and 15.6% respectively, and the complication rates in the experimental group were significantly lower than those in the control group (χ2 = 8.576, P <0.05). The frequency of speech in test group was significantly lower than that in control group (t = 3.202, P <0.05). Conclusion The treatment of secretory otitis media after radiotherapy of nasopharyngeal carcinoma by tympanic membrane catheter is superior to tympanic injection.