糖尿病是当前世界上严重威胁人类生命健康的慢性疾病之一。90%以上的糖尿病患者为2型糖尿病。近年来,随着我国经济水平快速发展、人口老龄化及生活方式的改变,2型糖尿病的发病率迅速增加,造成了巨大的社会负担。2型糖尿病的病理生理特点为外周组织胰岛素抵抗和(或)胰岛素分泌不足。国外研究表明,新诊断2型糖尿病患者的胰岛β细胞功能常常仅剩正常的50%左右[1,2]。研究提示,早期2型糖尿病患者β细胞并未真正 Diabetes is one of the chronic diseases in the world that seriously threaten the health of human beings. More than 90% of diabetics are type 2 diabetes. In recent years, with the rapid economic development in China, population aging and changes in lifestyle, the incidence of type 2 diabetes is rapidly increasing, resulting in a huge social burden. The pathophysiology of type 2 diabetes is characterized by peripheral insulin resistance and / or inadequate insulin secretion. Foreign studies have shown that newly diagnosed type 2 diabetes patients often have only about 50% of normal pancreatic β-cell function [1,2]. Research suggests that beta-cells in patients with early type 2 diabetes are not real