,Simultaneous and systematic analysis of cellular and viral gene expression during Enterovirus 71-in

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Dear Editor,Enteroviruses,including poliovirus,enterovirus 71 (EV71),enterovirus 68,coxsackievirus A16,cause millions of infections every year.The infection can lead to serious human diseases and is a significant public health problem.Among them,EV71 is an emerging pathogen that causes severe hand,foot and mouth disease (HFMD) and neurological disease,especially in young children.Currently,there is no effective treatment to EV71-caused diseases,partially blaming to a lack of understanding EV71 replication mechanism (Solomon et al.,2010).
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