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目的了解男性不育患者细菌感染的分布及药敏情况,为不育患者的治疗提供科学指导。方法对84份精液采用细菌分离培养、药敏纸片抑菌实验进行精液细菌学分析与药敏试验。结果84份男性不育患者精液标本细菌培养中阳性35份,占41.67%,阴性49份,占58.33%。35份阳性标本皆为检出一种细菌者,共分离出35株菌,分离率为41.7%;其中以金黄色葡萄球菌、表皮葡萄球菌为主,分别占74.2%、17.1%。所选10种抗生素纸片的药敏试验,葡萄球菌对万古霉素敏感率最高,其次为头孢唑林,头孢哌酮,庆大霉素,左氧氟沙星。结论不育男性精液的细菌感染分布以革兰阳性球菌为主,其中金黄色葡萄球菌所占的比例最高,在选用的抗生素当中,一、二、三代头孢菌素和喹诺酮类药物可以作为治疗用药。
Objective To understand the distribution and drug susceptibility of bacterial infection in male infertility patients and to provide scientific guidance for the treatment of infertility patients. Methods Seventy-four semen samples were isolated and cultured with bacteria. The bacteriostasis test was used to analyze the bacteriostasis and susceptibility test. Results Seventy-four male infertility patients were positive for bacterial culture, accounting for 41.67% and 49 negative, accounting for 58.33%. Among the 35 positive samples, 35 bacteria were isolated and the isolation rate was 41.7%. Staphylococcus aureus and Staphylococcus epidermidis accounted for 74.2% and 17.1% respectively. The susceptibility test of the 10 antibiotics disks selected showed that Staphylococcus was the most sensitive to vancomycin, followed by cefazolin, cefoperazone, gentamycin and levofloxacin. Conclusion The distribution of bacterial infection in infertile men is mainly Gram-positive cocci, of which Staphylococcus aureus accounts for the highest proportion. Among the selected antibiotics, the first-, second- and third-generation cephalosporins and quinolones can be used as therapeutic drugs .