导言及一般文献复習胃之慢性消化性溃瘍轉变为癌腫的問題,自一百多年以來,長期的引起臨床学家和病理学家之注意。远在1842年,Rokitansky氏即指出癌腫可能來自溃瘍基礎之上。1848年,Ditterich氏搜集160例胃癌,其中六例發生之地点与溃瘍相接近,而二例僅限于溃瘍之边緣,該氏即認为溃瘍和癌腫可偶而相互并存,但認前者并非致發后者之因子。至1858年,Brinton Introduction and General Literature Review The chronic peptic ulcer of the stomach has turned cancerous and has attracted the attention of clinical scientists and pathologists for more than one hundred years. As far back as 1842, Rokitansky’s stated that the cancer may have originated from ulcers. In 1848, Ditterich collected 160 cases of gastric cancer, of which 6 cases occurred close to ulcers, and 2 cases were limited to the edge of ulcers. The company believes that ulcers and cancers may occasionally co-exist, but the former are not The latter factor. By 1858, Brinton