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目的比较吡柔比星(THP)与丝裂霉素(MMC)膀胱灌注预防膀胱肿瘤术后复发的效果。方法将76例膀胱肿瘤术后患者根据用药要求分为MMC组32例,THP组45例,分别接受MMC、THP膀胱灌注,随访12~36个月。比较2组复发情况。结果复发率:MMC组为37.5%,THP组为11.1%;尿道狭窄发生率:MMC组为21.9%,THP组为4.4%;膀胱刺激症状发生率:MMC组为25%,THP组为4.4%。2组差异有统计学意义(P<0.05)。结论THP膀胱灌注预防膀胱肿瘤术后复发效果满意,优于MMC,THP膀胱灌注的不良反应明显少于MMC。
Objective To compare the effects of intravesical instillation of pirarubicin (THP) and mitomycin C (MMC) on the recurrence of bladder cancer. Methods Totally 76 patients with bladder cancer were divided into two groups according to the drug requirements: MMC group (32 cases) and THP group (45 cases). The patients were treated with MMC and THP respectively. The patients were followed up for 12 to 36 months. Compare the recurrence of the two groups. Results The recurrence rate was 37.5% in MMC group and 11.1% in THP group. The incidence of urethral stricture was 21.9% in MMC group and 4.4% in THP group. The incidence of bladder irritation was 25% in MMC group and 4.4% in THP group. . The difference between the two groups was statistically significant (P <0.05). Conclusion THP bladder irrigation is effective in preventing postoperative recurrence of bladder cancer, which is better than that of MMC. The adverse reaction of THP bladder irrigation is less than that of MMC.