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目的:测定胃癌患者血浆中纤溶酶原激活物(uPA)浓度变化情况,探讨uPA血浆含量变化作为胃癌恶性肿瘤诊断中的作用。方法:收集胃癌患者血液标本各40例,并以正常人血液标本作对照,用ELISA法检测肿瘤患者及正常对照组血浆中uPA的含量,并比较其差异。结果:与正常对照组(9.92±4.67 ng/ml)相比,胃癌(18.36±9.14 ng/ml)患者血浆中uPA含量明显升高,与正常组相比有显著性差异(P<0.05)。结论:血浆中的uPA浓度升高可作为胃癌诊断辅助指标,uPA参与胃癌的生物学过程。
OBJECTIVE: To determine the changes of plasminogen activator (uPA) in plasma of patients with gastric cancer and to investigate the changes of uPA plasma levels in the diagnosis of gastric cancer. Methods: Forty blood samples from patients with gastric cancer were collected, and the blood samples of normal people were used as control. The content of uPA in plasma of tumor patients and normal control group was detected by ELISA, and their differences were compared. Results: Compared with the normal control group (9.92 ± 4.67 ng / ml), the uPA level in gastric cancer patients (18.36 ± 9.14 ng / ml) was significantly higher than that in the normal control group (P <0.05). Conclusion: Increased uPA concentration in plasma can be used as an auxiliary indicator of gastric cancer diagnosis. UPA participates in the biological process of gastric cancer.