多形性胶质母细胞瘤(glioblastoma multiforme，GBM)是最具侵袭性的Ⅳ级星形细胞瘤，也是一种恶性程度最高的原发性恶性脑肿瘤，患者的中位生存期为15~17个月。目前GBM的常规治疗方法是手术切除、放疗和替莫唑胺化疗。肿瘤的侵袭性不仅是手术、放疗、化疗的主要障碍，也是GBM患者死亡的主要原因，并且GBM患者也会逐渐出现对化疗的耐药，从而导致肿瘤再生长或复发，但确切机制尚不十分清楚。近年来，缺氧在肿瘤转移和侵袭中的作用逐渐受到人们的广泛关注。了解缺氧如何诱导GBM细胞的侵袭性，对于研发新的更有效的治疗方法来对抗这种灾难性疾病显得尤为重要。目前认为缺氧可通过诱导GBM细胞外基质降解与重塑以及组织因子表达、促进上皮-间质的转化和血管生成、调控GBM离子通道等途径增加GBM的侵袭性。“,”Glioblastoma multiforme (GBM) is the most aggressive grade IV astrocytoma which is the common type of malignant (cancerous) primary brain tumor.The median survival time was 15-17 months.At present, the conventional treatment methods of GBM are surgical resection, radiotherapy and temozolomide chemotherapy of Temozolomide.The invasiveness of tumor is not only the main obstacle of surgery, radiotherapy and chemotherapy, but also the main cause of death of GBM patients.GBM patients will gradually develop resistance to chemotherapy, leading to tumor regrowth or recurrence, but the exact mechanism is not very clear.In recent years, the role of hypoxia in tumor metastasis and invasion has been paid more and more attention.Understanding how hypoxia induces GBM cell invasiveness is particularly important for developing new and more effective therapies to combat this catastrophic disease.It is believed that hypoxia can increase the invasiveness of GBM by inducing degradation and remodeling of extracellular matrix, expression of tissue factors, promoting epithelial mesenchymal transition and angiogenesis, and regulating GBM ion channels.