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目的观察中西医结合治疗脑卒中后抑郁症(PSD)的临床疗效。方法将入选的112例患者随机分为观察组和对照组各56例,对照组在神经内科常规治疗基础上给予口服黛力新及心理治疗;观察组在对照组治疗的基础上,按中医辨证分为肝郁气滞型、痰气郁结型、心脾两虚型、脾肾阳虚型,分别给予针对性方剂治疗。两组均治疗8周为1个疗程,疗程结束后观察两组患者的症状变化、汉密尔顿抑郁量表(HAMD)评分及不良反应。结果观察组临床治愈率为39.3%,总有效率为91.1%,明显高于对照组的21.4%和73.2%(P﹤0.01);HAMD量表评分比对照组明显改善(P﹤0.01);不良反应发生率较对照组明显减少(P﹤0.05)。结论中西医结合治疗PSD可明显提高临床治疗效果,减轻消化道和自主神经功能的不良反应,改善患者的生活质量,是一种值得推广的联合治疗方案。
Objective To observe the clinical efficacy of integrated traditional Chinese and western medicine in the treatment of post-stroke depression (PSD). Methods One hundred and twelve patients were randomly divided into observation group and control group, with 56 cases in each group. The control group was given oral Deanxit and psychotherapy on the basis of conventional treatment of neurology. On the basis of the treatment of the control group, Divided into liver qi stagnation, phlegm stagnation type, heart and spleen deficiency type, spleen and kidney yang type, were given targeted prescription treatment. Two groups were treated for 8 weeks for a course of treatment, after the end of the treatment were observed symptoms, Hamilton Depression Rating Scale (HAMD) score and adverse reactions. Results The clinical cure rate was 39.3% in the observation group and the total effective rate was 91.1%, which was significantly higher than that of the control group (21.4% vs 73.2%, P <0.01). The HAMD scale score was significantly improved (P <0.01) The incidence of reaction was significantly lower than that of the control group (P <0.05). Conclusion The combination of traditional Chinese and Western medicine treatment of PSD can significantly improve the clinical treatment, reduce gastrointestinal and autonomic dysfunction, improve patient quality of life is a worthy of promotion of the joint treatment.