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报道了利用 30 mml/L HAc-NaAc为缓冲液测定复方新诺明中甲氧苄胺嘧啶(TMP)和磺胺甲基异噁唑(SMZ)的离解常数及含量的毛细管区带电泳(CZE)方法。该方法具有简便、快速、准确等特点。测得TMP和SMZ的pKa分别为6.60和5.90。其平均回收率分别为101.5%和99.6%,最低检出限为0.48 mg/L和0.028 mg/L,RSD为1.26%和1.12%。
Reported the determination of the dissociation constants and contents of trimethoprim (SMP) and sulfamethoxazole (SMZ) in cotrimoxazole with 30 mml / L HAc-NaAc as buffer solution by capillary zone electrophoresis (CZE) method. The method is simple, fast and accurate. The pKa of TMP and SMZ were measured as 6.60 and 5.90, respectively. The average recoveries were 101.5% and 99.6%, respectively, and the lowest detection limits were 0.48 mg / L and 0.028 mg / L with RSDs of 1.26% and 1.12%, respectively.