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本文从探讨一种既保留雌激素对骨的保护作用,又可避免长期应用可能对某些器官和组织产生副作用的药物,用于绝经后妇女防治骨质疏松的药物即SERM倍受关注,此文从SERM的特征,分类及作用机理进行论述,旨在分析SERM治疗绝经后老年骨质疏松症的药理研究,雌激素仍是绝经后妇女激素补充治疗的首选药物,RAL则有待进一步探讨。
This article explores a protective effect of both preserving estrogen on bone and avoiding long-term use of drugs that may have side effects on certain organs and tissues. The drug for preventing and treating osteoporosis in postmenopausal women is of great concern, The article discusses the characteristics, classification and mechanism of SERM in order to analyze the pharmacological research of SERM in the treatment of postmenopausal senile osteoporosis. Estrogen is still the first choice of hormone replacement therapy in postmenopausal women. RAL needs to be further explored.