目的观察大剂量甲氨蝶呤治疗原发性中枢神经系统淋巴瘤疗效及护理对策。方法选取2011年5月至2016年5月间天坛医院收治的50例原发性中枢神经系统淋巴瘤患者。采用随机数字表法分为观察组与对照组,每组25例。两组均采用大剂量甲氨蝶呤治疗,观察组患者给予针对性护理干预,对照组患者给予常规护理,比较两组患者的临床疗效和不良反应情况。结果观察组患者治疗总有效率为92.0%,对照组为88.0%,差异无统计学意义(P>0.05)。观察组患者术后不良反应发生率为28.0%,显著低于对照组的64.0%,差异有统计学意义(P<0.05)。结论大剂量甲氨蝶呤是治疗原发性中枢神经系统淋巴瘤的有效药物,采用针对性护理干预可有效强化治疗效果,降低不良反应发生率。 Objective To observe the efficacy and nursing strategies of high-dose methotrexate in the treatment of primary central nervous system lymphoma. Methods From May 2011 to May 2016, 50 patients with primary central nervous system lymphoma admitted to Tiantan Hospital were enrolled. Using random number table divided into observation group and control group, 25 cases in each group. Both groups were treated with high-dose methotrexate, and the patients in the observation group were given targeted nursing intervention. The patients in the control group were given routine nursing care. The clinical efficacy and adverse reactions of the two groups were compared. Results The total effective rate was 92.0% in the observation group and 88.0% in the control group, with no significant difference (P> 0.05). The incidence of postoperative adverse reactions in the observation group was 28.0%, which was significantly lower than that in the control group (64.0%), the difference was statistically significant (P <0.05). Conclusion High-dose methotrexate is an effective drug for the treatment of primary central nervous system lymphoma. Targeted nursing intervention can effectively enhance the therapeutic effect and reduce the incidence of adverse reactions.