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目的了解糖皮质激素对治疗慢性阻塞性肺部疾病急性加重(AECPOP)是否有效,口服糖皮质激素7d和14d对AECOPD的疗效是否相同。方法对130例AECOPD患者随机分成三组:7d治疗组、14d治疗组及安慰组。试验前后观察肺功能、血气分析、住院天数、治疗失败率、激素副反应及复发率。结果激素组与治疗组相比,肺功能提高,治疗组与安慰组比较,P=0.026,7d治疗组与14d治疗组相比无明显统计学意义。结论口服激素对AECOPD治疗有效,但疗程为7d与14d无明显差异。
Objective To investigate whether glucocorticoid is effective in treating acute exacerbation of chronic obstructive pulmonary disease (AECOPO) and whether oral glucocorticoid has the same effect on AECOPD at 7 and 14 days. Methods 130 AECOPD patients were randomly divided into three groups: 7d treatment group, 14d treatment group and comfort group. Before and after the test, lung function, blood gas analysis, hospital days, treatment failure rate, hormone side effects and recurrence rate were observed. Results Compared with the treatment group, the hormone group improved pulmonary function. Compared with the control group, there was no significant difference between the treatment group and the control group (P = 0.026 and 7d). Conclusions Oral hormones are effective in AECOPD treatment, but there is no significant difference between 7d and 14d.